[TLDR] I dont understand the fault people had/have with Richard Goldscmidt's concept of systemic mutations [/TLDR]
As a preface, I am a undergrad biology student, so sorry if this is a "Stupid question".
How does Richard Goldschmidt's concept of systemic mutations, reject the classical gene concept, why were biologists so against it?
From what I understand he used the concept of systemic mutations and developmental macromutations in his lectures to explain how macromutations could cause speciation(macroevolution?). The results of the developmental macromutations, if I understand him correctly would be then the Hopeful Monsters?
And from what I have read on a timeline of his work, systemic mutations describe the "large rearrangments of the chromosome", with a new arrangement meaning a new phenotype?
How is that wrong though? Do chromosomes not have rearrangements via cross over events during meiosis or via transposable elements? Or is he referring to something else, since I understand at the time, meiosis and TE's were not understood well.
The source i was reading from was: (Richard Goldschmidt: hopeful monsters and other 'heresies' by Michael R. Dietrich) Available from http://www.dartmouth.edu/~dietrich/NRG2003.pdf