I have the following facts:
- It is possible to convert ATP <-> creatine vice-versa. (ref - non scientific)
- CP supplementation protects against metabolic syndrome. ref1 ref2
- Fructose digestion depletes NADH via TG synthesis. ref
I assume that CP supplementation regenerates not just ATP, but NADH, if it is depleted, and so it restores the redox balance in the liver. Both ATP and NADH are similar energy storing molecules, so I guess there is a biochemical pathway which converts ATP to NADH, or there is a pathway, which regenerates NADH using CP. Am I right, if so, which pathway is it?
I might be wrong. From one of the references:
Taken together, this study provides direct evidence that creatine reduces lipid accumulation in hepatocytes by the stimulation of fatty acid oxidation and TG secretion.
So maybe ATP is enough to prevent TG accumulation in the liver.