I have been analyzing TCGA Ovary Cancer data. In Somatic Mutation data, there is data of mutations in all the chromosomes (1-22 and X), but amazingly, I have found one (just one) row of Y Chromosome mutation as well. What can it mean?

For Reference, I have pasted that row below:

icgc_mutation_id icgc_donor_id project_code chromosome chromosome_start 
MU42454          DO28056       OV-US        Y          13500742         

chromosome_end chromosome_strand mutation_type            
13500742       1                 single base substitution 

reference_genome_allele mutated_from_allele mutated_to_allele 
G                       G                   A                 

consequence_type aa_mutation cds_mutation gene_affected   transcript_affected 
stop_gained      R194*       580C>T       ENSG00000183704 ENST00000331172
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    $\begingroup$ In just one individual you mean? It means that there was a rare recombination event I guess in the father (or grand-father or grand-grand...-father) $\endgroup$ – Remi.b Apr 23 '15 at 1:03
  • $\begingroup$ Yeah it is for one individual and only one entry: Individual is a 76yo female (deceased) $\endgroup$ – Failed Scientist Apr 23 '15 at 1:05
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    $\begingroup$ Does it correspond to a region the is close to the PAR? $\endgroup$ – Remi.b Apr 23 '15 at 1:06
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    $\begingroup$ Just to expand on what @Remi.b said, there is the possibility that at some point in the past, in a male ancestor, a rare event occurred where a portion of the Y chromosome somehow ended up grafted to an X chromosome (or possibly any one of the others), but didn't cause enough issues/abnormalities to be an issue, or at least noted. $\endgroup$ – MattDMo Apr 23 '15 at 1:08
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    $\begingroup$ Its not in PAR of either X or Y $\endgroup$ – Failed Scientist Apr 23 '15 at 2:28

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