I just got out of a lecture on mitosis and this part was incredibly confusing. After searching my textbook it doesn't cover it that well either.

The professor mentioned a NUMA protein that is released after NEBD, and that it helps form more Microtubules. I don't really understand how it does this.

Is it just a protein that sits in the pericentriolar matrix and encourages microtubule nucleation? Or is it a a kinase that deactivates some GAPs that destabilize microtubules?

Also, if you would like, there's also this study question I feel is sort of related: What are two proteins located in the pericentriolar matrix that encourage microtubule nucleation?

I feel like one of them is the y-tubulin ring complex. Would the other be NUMA?

Thanks for reading.

  • 1
    $\begingroup$ you should ask your professor if you have doubts about a lecture. you can read about NuMA here $\endgroup$ – WYSIWYG May 5 '15 at 17:30

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