I just got out of a lecture on mitosis and this part was incredibly confusing. After searching my textbook it doesn't cover it that well either.
The professor mentioned a NUMA protein that is released after NEBD, and that it helps form more Microtubules. I don't really understand how it does this.
Is it just a protein that sits in the pericentriolar matrix and encourages microtubule nucleation? Or is it a a kinase that deactivates some GAPs that destabilize microtubules?
Also, if you would like, there's also this study question I feel is sort of related: What are two proteins located in the pericentriolar matrix that encourage microtubule nucleation?
I feel like one of them is the y-tubulin ring complex. Would the other be NUMA?
Thanks for reading.