Does cancer by any chance fall under host pathogen interaction domain? What I mean to ask is that, is there pathogen interaction involved in cancer? I went through this article:


In the cancer category they have used the phrase "can be cause" by this and this pathogen.. Isn't cancer a disease that occurs due to abnormal growth of cells due to genetic change?


No not necessarily. Cancer can also be caused by bacteria and viruses in your body

The regulation of cancerous tumor development is converged upon by multiple pathways and factors. Besides environmental factors, gastrointestinal (GI) tract cancer can be caused by chronic inflammation, which is generally induced by bacteria, viruses, and parasites. The role of these inducers in cancer development, cell differentiation and transformation, cell cycle deregulation, and in the expression of tumor-associated genes cannot be ignored.

Although Helicobacter pylori activates many oncogenic pathways, particularly those in gastric and colorectal cancers, the role of viruses in tumor development is also significant. Viruses possess significant oncogenic potential to interfere with normal cell cycle control and genome stability, stimulating the growth of deregulated cells. An increasing amount of recent data also implies the association of GI cancers with bacterial colonization and viruses.

You can read more here: Aituov, Bauyrzhan, et al. "Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm." Infectious agents and cancer 7.1 (2012): 18.

  • $\begingroup$ can pathogens initiate cancer? or do they just add to the problems in human body when it is affected by cancer?? $\endgroup$
    – girl101
    May 15 '15 at 9:03
  • 1
    $\begingroup$ @user3237995 Did you read the paper I mentioned...the answer is in there. $\endgroup$
    – Rover Eye
    May 15 '15 at 9:05

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