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I was reading a paper by Tang & Othmer about oscillations and waves in Dictyostelium discoideum. Under certain condition like starvation period in the life cycle of a Dictyostelium discoideum community, they evolve itself into a multicellular organism in a process of cellular aggregation. I have read about Pacemaker cells among these individuals which transmits periodic cAMP and attracts other cells towards them.

So I was wondering: When and How do these Pacemaker cells develop from a "normal" cell into a pacemaker cell excreting cAMP?

References, links or answers would be very helpful for me.

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    $\begingroup$ What exactly do you mean: 1) How are they are evolving (into the next coming million years?); 2) How did they evolve (in the last couple of million years?) or 3) How they come into being in a micro environment like an erlenmeyer flask with cAMP floating around (wax and waning effect in a few hours time)? $\endgroup$
    – AliceD
    May 22, 2015 at 10:06
  • $\begingroup$ AliceD : By evolving, I mean how do some cells "become" Pacemakers. $\endgroup$
    – dexterdev
    May 22, 2015 at 10:12
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    $\begingroup$ Thanks. I have linked that same article again you linked before, as it is the same literature you are referring to am I right? $\endgroup$
    – AliceD
    May 22, 2015 at 10:14
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    $\begingroup$ @AliceD : Done. I have attached the paper. $\endgroup$
    – dexterdev
    May 22, 2015 at 10:19
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    $\begingroup$ We were working on it simultaneously: all good :) Thanks! +1 $\endgroup$
    – AliceD
    May 22, 2015 at 10:20

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