Age-associated neurodegenerative diseases encompass Alzheimer's Disease and Parkinson's Disease. What other neurodegenerative diseases could be described as age-associated? Multiple Sclerosis? Brain tumors? What might be the criteria for defining a disease as age-associated, specifically in the realm of neurobiology?


Dementia with Lewy bodies (DLB): It is characterized anatomically by the presence of Lewy bodies, clumps of alpha-synuclein and ubiquitin protein in neurons, detectable in post-mortem brain histology.[1] Lewy Body dementia affects 1.3 million individuals in the United States alone.


Binswanger disease is a form of small vessel vascular dementia caused by damage to the white brain matter.[1] White matter atrophy can be caused by many circumstances including chronic hypertension as well as old age.[2] This disease is characterized by loss of memory and intellectual function and by changes in mood. These changes encompass what are known as executive functions of the brain.[3] It usually presents between 54 and 66 years of age, and the first symptoms are usually mental deterioration or stroke.[4]


To name the two with the highest prevalence after Alzheimer's and Parkinson's.

  • $\begingroup$ And what of MS, and a definition? Should age-association be defined by epidemiological studies or some other way? $\endgroup$ Sep 12 '12 at 18:02

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