2
$\begingroup$

The G zipper motif is found in transmembrane proteins at an above random frequency and there are models explaining how it might help with multiple transmembrane intra-membrane helix bundle assembly.

However there are a bunch of different "flavours" of these G zipper motifs. Here are the ones I have come across so far:

  • GXXXG
  • GVXXGV
  • GXXXGXXXG
  • AXXXGXXXG
  • SXXXGXXXG
  • GXXXGXXXS
  • GXXXGXXXT

I don't think I am completely up to date so that is a non-exhaustive list. Have I missed any? Broadly speaking what accounts for their variation?

note: X refers to a non specific amino acid in FASTA protein sequences.

$\endgroup$
  • 1
    $\begingroup$ It seems to be a small family as per pfam. And frankly I had never heard of glycine zippers till now (so thanks for that). Perhaps this may be useful. $\endgroup$ – WYSIWYG Jun 28 '15 at 18:43

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Browse other questions tagged or ask your own question.