4
$\begingroup$

IP3 molecules bind to IP3 receptors and open up the calcium channels on the endoplasmic reticulum. I am wondering what happens to IP3 molecules after they have been released from the IP3 receptor? Do they remain as IP3 molecules, or do they break down? Do they have any purpose after they have been released, and perhaps after been broken down?

$\endgroup$
5
$\begingroup$

All biomolecules are eventually broken down. This process is called turnover. Since inositol is a signalling molecule it is necessary to remove in order to terminate the signal, despite adaptive mechanism in the ER calcium channels.

IP3 is generally dephosphorylated by a family of phosphatase enzymes called inositol polyphosphate phosphatases. After dephosphorylation, the inositol can be recycled into the membrane by phosphatidyl-inositol synthase.

Reference:

The IUPHAR/BPS Guide to PHARMACOLOGY 1


1 I'm citing this website instead of a research article because apart from citing the original research articles, it also has other informative links about the enzymes and the substrate molecules. It is also from a very reliable source.

$\endgroup$
  • $\begingroup$ thank you so much @wysiwyg By the way, how do we know the lifetime of such signalling molecules. $\endgroup$ – nashynash Jul 9 '15 at 10:57
  • 2
    $\begingroup$ @nashynash There are different assays by which it can be found out. One way is to label the metabolite using an isotope (like ¹³C) and track the loss of radioisotope in the sample using mass spectrometry or NMR. In this case the "lifetime" depends on the phosphorylated state of inositol - so the phosphorous has to be labelled instead of carbon. $\endgroup$ – WYSIWYG Jul 9 '15 at 11:11

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.