A few days ago I read about MHC1 knockout pigs for organ transplantation research. I was just wondering, is it enough to knock out MHC1 in the donor (lets say from same species, pig to pig) for successful transplantation?
I understand that someone without MHC1 is more sensitive to viruses, cancer, to NK and more. But the study pigs lived fine, so in theory it is possible to have knockout MHC1 and survive. But is it enough for successful transplantation from one pig (donor with knockout) to another (fully healthy, normal pig) ?