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I've read from an academic article that diamine oxidase cannot be supplemented but it had no explanation as for why. I am curious as to why this?

Food rich in histamine or red wine may cause allergy‐like symptoms such as sneezing, flush, skin itching, diarrhoea and even shortness of breath. The suspected reason is a diminished histamine degradation based on a deficiency of diamine oxidase. As diamine oxidase cannot be supplemented, a histamine‐free diet was implemented to reduce histamine intake.

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    $\begingroup$ Proteins other than hormones in general are not supplementable. Think of genetic retinitis pigmentosa, metabolic diseases etc. They are digested when taken orally and won't reach intracellular targets when injected in the bloodstream or in tissues. $\endgroup$
    – AliceD ♦
    Jul 11 '15 at 5:01
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The article nowhere mentions diamine oxidase(DAO) cannot be suplemented.

DAO supplementation

The link clearly supports DAO can be used. Though Triptans like sumatriptans are used because of cost.

Note: Research is of 2018, so not your fault. 😜

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