What determines whether an action potential is inhibitory or excitatory? Is it determined by the receptors, the neurotransmitters, or some other mechanism?


1 Answer 1


Short answer
The physiological state of the postsynaptic cell ultimately determines the effect of an incoming action potential.

An action potential occurring in a chemical synapse is neither inhibitory or excitatory. An action potential is a binary '1', an-all-or-nothing signal without any information, i.e., there is not a -1 or +1 action potential. Similarly, there are no excitatory or inhibitory neurotransmitters.

Notably, the principal excitatory neurotransmitter in the nervous system, glutamate, can have inhibitory effects dependent on the receptor activated. While most metabotropic glutamate receptors (mGluRs) and ionotropic AMPA and NMDA receptors are indeed all excitatory, the inhibitory glutamate receptors (iGluRs) are not (Cleland, 1996).

Conversely, GABA, the principal inhibitory neurotransmitter in the nervous system, can have excitatory postsynaptic effects. For example, hyperpolarized neurons may actually depolarize upon GABAA receptor activation, simply because the resting membrane potential is more negative than the reversal potential of Cl- (i.e., Cl- flows out of the cell due to the negative membrane potential) (Marty & Liano, 2005).

The existence of both excitatory and inhibitory glutamate receptors shows that it is the postsynaptic receptor that determines whether an action potential will inhibit or excite the postsynaptic neuron. The excitatory effect of GABAA activation shows that on top of that, even principal inhibitory neurotransmitters (GABA) with principal inhibitory receptors (GABAA) can excite a neuron dependent on its physiological state.

Besides chemical synapses there are electrical synapses. In these synapses action potentials are transmitted directly electrically through gap junctions. In this case, any action potential is excitatory as the signal will be carried forward if it is strong enough (Purves et al., 2001).

- Cleland, Mol Neurobiol (1996); 13(2): 97-136
- Marty & Liano, Trends Neurosci (2005); 28(6): 284-9
- Purves et al., Neuroscience, 2nd ed. Sunderland (MA): Sinauer Associates; 2001.

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    $\begingroup$ After reading your answer, my impression is my question is a bit nonsensical. Does it seem that way to you? I can't tell if I asked a meaningless question or the answer is "it depends and without further info that can't be specified." Thanks for replying btw. $\endgroup$ Commented Jul 22, 2015 at 1:58
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    $\begingroup$ I think your question makes a lot of sense, because too many people talk about excitatory neurotransmitters and the likes. There are no inhibitory or excitatory neurotransmitters. +1 for the question. $\endgroup$
    – AliceD
    Commented Jul 22, 2015 at 2:00
  • $\begingroup$ @AliceD, I'd vote for peppering in a few judicious "strictly speaking"s to your answer, since I'd bet most working neuroscientists would give a minor eye roll to your italicized comment point. $\endgroup$
    – Chelonian
    Commented Jul 25, 2015 at 3:25
  • $\begingroup$ @Chelonian - I'm a working neuroscientist. Which comment are you addressing? $\endgroup$
    – AliceD
    Commented Jul 25, 2015 at 4:18
  • $\begingroup$ @Chelonian - and given the nature of the question I don't think any eye roll would be rather misplaced. $\endgroup$
    – AliceD
    Commented Jul 25, 2015 at 4:34

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