According to wikipedia on chimeric genes:

These mutations are distinct from fusion genes which merge whole gene sequences into a single reading frame and often retain their original functions.

I am not totally sure I understand the statement. My interpretation is that a fusion gene is caused by a translocation of DNA in a single gene; therefore, it "retains their original functions". This is different from a chimeric gene where DNA from two or more different genes are translocated to a new location to form a completely new gene.

Is my interpretation correct?


A chimeric gene is formed from fragments of other genes whereas a fusion gene is formed from the entirety of other genes. Often in the literature you'll see the term fusion gene used for both cases.


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