I was going through this paper, but did not understand a term.
What is the meaning of functional screen?

(I am not a biology student, I don't understand much, and a small simple explanation would be enough)


1 Answer 1


From the abstract of the linked article (Guttman, 2002):

We used an in vivo genetic screen to identify 13 effectors [...]. Although sharing little overall homology, the amino-terminal regions of these effectors had strikingly similar amino acid compositions.

And from the body:

The screen relied on the type III secretion signal and the endogenous promoter of the hop gene and was thus highly specific.

Hence, the authors search and identify proteins with a secretory signal under the regulation of a hop promoter. A functional screen in this paper refers to the analysis of protein samples to detect the presence of proteins with a particular function.


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