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The PDCH@ cluster of genes share exons and are therefore isoforms of each other. However, they are considered separate genes, by both HUGO and Ensembl.

A "gene" is defined as "a locus of co-transcribed exons" (Venter 2001), and this locus clearly fits that definition with no ambiguity. So why are these transcripts considered separate genes?

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  • $\begingroup$ What is your question exactly? $\endgroup$
    – AliceD
    Commented Aug 10, 2015 at 22:59
  • $\begingroup$ The question is, why are these transcripts considered separate genes? $\endgroup$
    – thc
    Commented Aug 11, 2015 at 0:04
  • $\begingroup$ Thanks, I slightly modified the question to improve clarity. Feel free to roll back. You may want to add a link to Venter, 2001 too. And transcripts are not genes. $\endgroup$
    – AliceD
    Commented Aug 11, 2015 at 0:13
  • $\begingroup$ Related: biology.stackexchange.com/questions/31766/… $\endgroup$
    – canadianer
    Commented Aug 11, 2015 at 3:28

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I would say they are considered different genes because each isoform is under the control of its own promoter.

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  • $\begingroup$ Having multiple promoters doesn't mean isoforms are different genes. E.g., pnas.org/content/97/5/2291.full $\endgroup$
    – thc
    Commented Aug 12, 2015 at 4:21

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