I have read an answer to a question about dna repair during and after replication.

But how is dna repaired if a deamination of of 5-methylcytosine happens? How does a repair mechanism identify which base was mutated (on '3 or on '5 strand, a C to T, or on the complementary strand an A to G)?

  • $\begingroup$ I don't have time for an answer right now, but you can look up very short patch repair for bacteria. For higher organisms where methyl-C occurs in CpG sites, repair enzymes can recognize the mutated strand by the presence of methylated CpG on the complementary strand. $\endgroup$ – canadianer Sep 1 '15 at 15:18
  • $\begingroup$ DNA Glycosylases, like UDG, and hSMUG1 contribute to specifically sniffing out instances of Uracil that occur in the DNA. Havent time for a full answer myself, but these are just a few resources. $\endgroup$ – CKM Sep 1 '15 at 21:20
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    $\begingroup$ Deamination of 5mC gives T, not U. $\endgroup$ – canadianer Sep 1 '15 at 21:57
  • $\begingroup$ Yikes, that's embarrassing! Disregard my above comment unless you're curious! $\endgroup$ – CKM Sep 1 '15 at 23:59

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