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Why is it that white blood cells (leukocytes) are highly characterized in DNA methylation pure cell line profiling, but I can't find any profiles of red blood cells (erythrocytes)? Is blood considered a pure tissue type?

I'm following the deconvolution of DNA methylation data by cell type (white and red), but I can't do this without pure cell line methylation data. Can anyone help me understand either:

  1. Why red blood cell DNA methylation data has not been purified and collected yet.

OR if it has...

  1. Where can I access the methylation data for red blood cells (erythrocytes)?

Thanks so much for any help!!!

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The answer is relatively simple: Mature erythrocytes do not have a nucleus and thus you cannot study methylation patterns there. You can do this in young, developing erythrocytes which still have their nucleus.

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