1
$\begingroup$

Why is it that white blood cells (leukocytes) are highly characterized in DNA methylation pure cell line profiling, but I can't find any profiles of red blood cells (erythrocytes)? Is blood considered a pure tissue type?

I'm following the deconvolution of DNA methylation data by cell type (white and red), but I can't do this without pure cell line methylation data. Can anyone help me understand either:

  1. Why red blood cell DNA methylation data has not been purified and collected yet.

OR if it has...

  1. Where can I access the methylation data for red blood cells (erythrocytes)?

Thanks so much for any help!!!

Improve this question
$\endgroup$
0
1
$\begingroup$

The answer is relatively simple: Mature erythrocytes do not have a nucleus and thus you cannot study methylation patterns there. You can do this in young, developing erythrocytes which still have their nucleus.

Improve this answer
$\endgroup$

Your Answer

By clicking “Post Your Answer”, you agree to our terms of service, privacy policy and cookie policy

Not the answer you're looking for? Browse other questions tagged or ask your own question.