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Why is that often when alpha-helices are discussed, it is also mentioned their direction - right-handed (clockwise) or left-handed (anti-clockwise)?

I have heard that left-handed alpha-helices are usually less stable, but I'm sure there is more to it than that?

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Some experimental and modelling observations suggests, folding energy for right handed in more favorable. You can find more detailed answer to this question here.

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