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A chromosomal male is XY and a chromosomal female is XX. Now imagine if, one day, this world has only males - is it possible to "recreate" a female by using two X chromosomes from two different males?

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    $\begingroup$ Do you want to clone yourself with certain benefits? $\endgroup$ Sep 30, 2015 at 14:13

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Short answer
Technologically yes, but practically no, because there would be no surrogate mother available to bring the artificial XX zygote to term.

Background
Theoretically a cell with two male Xs can be generated, given that it is technically possible to shuttle single chromosomes between cells (Paulis, 2011).

However, assuming that in your future world oocytes are available from oocyte banks and sperm from sperm banks just like they are today, then the artificial combination of two Xs from male cells wouldn't be necessary in the first place, as regular IVF could be used.

Note that in both the chromosome transfer and IVF scenario, a female would still be necessary to implant the zygote. Until artificial wombs become available (they are not), it is impossible to generate females without females.

Reference
- Paulis, Methods Mol Biol (2011); 738: 57-67

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  • $\begingroup$ So, with artificial womb, we can do that? We can recreate female using two X's from men? $\endgroup$
    – PaulD
    Sep 30, 2015 at 12:29
  • $\begingroup$ @JesusChrist - Given that we can transfer chromosomes between cells, I can see no reason why not. $\endgroup$
    – AliceD
    Sep 30, 2015 at 13:04
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    $\begingroup$ @JesusChrist, and it's probably unwise to do so. Any recessive traits on your X chromosome are, by default, winners - you're just shortening up the generational problems experienced by inbreeding. Caveat: I'm not a biologist, but that's the way I understand it to work. $\endgroup$
    – Jason
    Sep 30, 2015 at 13:40
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    $\begingroup$ @JesusChrist Your name is just godly for this question. $\endgroup$
    – nwp
    Sep 30, 2015 at 15:13
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    $\begingroup$ Note that not only mammals have XY sexual chromosomes and your answer assumes we are talking about mammals. I assume the OP was thinking of mammals as well so it is fine but it might be worth to add a note $\endgroup$
    – Remi.b
    Oct 9, 2015 at 23:46

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