I read that this proteins lack of slicer activity, so what mechanism do they use to perform gene regulation?
Paper by Zinovyev and colleagues in the paper "Mathematical modeling of microRNA‐mediated mechanisms of translation repression" find that there are reports to 9 different mechanisms of miRNA-regulation.
Here we are reviewing available experimental data on all reported mechanisms of microRNA action, grouping them in a way which elucidates the main details supporting each of these proposed mechanisms.
Here is a list of the mentioned mechanisms:
M1: Cap-40S Initiation Inhibition
M2: 60S Ribosomal Unit Joining Inhibition
M3: Elongation Inhibition
M4: Ribosome Drop-Off
M5: Co-translational Nascent Protein Degradation
M6: Sequestration in P-Bodies
M7: mRNA Decay
M8: mRNA Cleavage
M9: Transcriptional Inhibition Through microRNA-Mediated Chromatin Reorganization Following by Gene Silencing
Also here is a link to the Pubmed entry of the article: