Rheumatoid Factor (RF) attacks Fc portion of Immunoglobulin G (IgG), I want to know the underlying mechanism at molecular level. Also, what type of bond or attachment is made by RF and Fc portion of IgG?

// I'm a student of mathematical physics and have no detailed knowledge in biology, this question comes in my mind because my sister is suffering from Rheumatoid arthritis. All I want is to understand this disease from physical aspects//


RF factors comprise antibodies that your body makes that exhibit auto-immunity (recognition of self as an antigen). They often recognize and bind to IgG antibodies as illustrated in this picture: RF binding to IgG

So the answer to your first question is that the underlying mechanism is inappropriate recognition of self from your immune system.

For your second question, I am not an expert in the type of chemical bonds employed by antibody-antigen interactions, so I looked it up briefly. This article was quite informative for that: Antibody/Antigen Complexes. The majority of binding seems to be hydrogen and ionic binding.

Hope that gets you going in your own searches.

  • $\begingroup$ Thanks sir, the link helped me a lot. I was searching something special in bonding of RF & IgG so that we can separate them via external forces. Here uniqueness and speciality is important in the RF-IgG bond because in breaking the bonds from external forces can destroy the bonding between another antigen and antibodies. $\endgroup$ – user56396 Oct 24 '15 at 20:11
  • $\begingroup$ Great. Mark my answer if it answered your question. That is how it works. $\endgroup$ – akaDrHouse Oct 24 '15 at 22:37
  • $\begingroup$ But I didn't get unique property of RF-IgG bond, the bonding between antigen and antibodies are generalized in that link. $\endgroup$ – user56396 Oct 25 '15 at 1:09
  • $\begingroup$ Antibodies have variable regions that are just that. Through VDJ recombination, this could be a multitude of ways. I don't know of a way to characterize a unique binding pocket for this process. You might be able to do so if you could crystallize a monoclonal AB/IgG protein complex. But my understanding in humans would be you would have many different auto antibodies coming from different B cells. Anyone else that can chime in, please do. $\endgroup$ – akaDrHouse Oct 25 '15 at 2:38

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