Why do most mammals produce their own Vitamin C?

Why do Humans not?


Humans do not produce Vitamin C due to a mutation in the GULO (gulonolactone oxidase) gene, which results in the inability to synthesize the protein. Normal GULO is an enzyme that catalyses the reaction of D-glucuronolactone with oxygen to L-xylo-hex-3-gulonolactone. This then spontaneously forms Ascorbic Acid (Vitamin C). However without the GULO enzyme, no vitamin C is produced.

This has not been selected against in natural selection as we are able to consume more than enough vitamin C from our diet. It is also suggested that organisms without a functional GULO gene have a method of "recycling" the vitamin C that they obtain from their diets using red blood cells (see Montel-Hagen et al. 2008).

A 2008 published study (Li et al. 2008) claimed to have successfully re-instated the ability to produce vitamin C in mice.

Simply as trivia: other than humans; guinea pigs, bats and dry-nosed primates have lost their ability to produce vitamin C in the same way.


  • Li, Y., Shi, C.-X., Mossman, K.L., Rosenfeld, J., Boo, Y.C. & Schellhorn, H.E. (2008) Restoration of vitamin C synthesis in transgenic Gulo-/- mice by helper-dependent adenovirus-based expression of gulonolactone oxidase. Human gene therapy. [Online] 19 (12), 1349–1358. Available from: doi:10.1089/hgt.2008.106 [Accessed: 31 December 2011].

  • Montel-Hagen, A., Kinet, S., Manel, N., Mongellaz, C., Prohaska, R., Battini, J.-L., Delaunay, J., Sitbon, M. & Taylor, N. (2008) Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C. Cell. [Online] 132 (6), 1039–1048. Available from: doi:10.1016/j.cell.2008.01.042 [Accessed: 31 December 2011].

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    $\begingroup$ Interestingly Linus Pauling thought that this was a fundamental defect in animals and that vitamin supplements could restore human health against disease and illness. Characteristically he wrote a book about vitamins and started the dietary supplement industry as we know it today. Uncharacteristically, he was probably wrong about how much vitamins we need. $\endgroup$ – shigeta May 17 '12 at 16:10

protected by Community Jun 6 '14 at 20:46

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