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I was going through this webpage and I found the following lines:

We hypothesised that despite unimodal distribution of CD4 co-receptor on naïve CD4 T cells they are not homogenous in their function.By testing naïve CD4 population from mice and humans expressing highest and lowest (~10%) levels of CD4 in a variety of functional assays we find that indeed naïve CD4 cells with high CD4 levels respond much better to activation and survive more easily post-activation.

Now what does "CD4 level" means? How is the CD4 receptors distribution obtained? With repect to the value of which feature is it obtained?(If you are not able to understand the last question, let me know, I will try to explain more in details)

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  • $\begingroup$ In this case, I would email the corresponding author of the article and request that they provide you with a definition of what High means. A scientific text should not use vague qualitative descriptions like that. They should provide you with at the very least a range of what they classify as high, low, and normal expression of CD4 receptors. $\endgroup$ – AMR Nov 16 '15 at 5:04
  • $\begingroup$ and what does just CD4 level mean?? $\endgroup$ – girl101 Nov 16 '15 at 5:10
  • $\begingroup$ The number of CD4 co receptors on a CD4 T-Cell... when the T-Cell Receptor binds to MHC II the interaction is stabilized by the CD4 coreceptor. It binds to the side of the MHC II receptor on the Antigen Presenting Cell and greatly increases the efficiency of binding. I thought with the second question that you understood that CD4 refers to plasma membrane receptors on the surface of helper T-Cells. $\endgroup$ – AMR Nov 16 '15 at 5:13
  • $\begingroup$ okay okay, it is my fault actually, i was not able to frame it properly $\endgroup$ – girl101 Nov 16 '15 at 5:21
  • $\begingroup$ @AMR it looks like the answer is in the question - "high" and "low" were defined as the 10% on either side of the curve... $\endgroup$ – MattDMo Nov 18 '15 at 2:08

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