Imagine a scenario in which some person is unable to absorb any dietary cholesterol because of some intestinal mutation (for example). Thus, they have no cholesterol available from their diet for steroid hormone synthesis, bile acid synthesis, or any other process that requires cholesterol.
If that person had to synthesize all of their cholesterol requirements de novo (i.e. from acetyl-CoA), how much energy would that require on a daily basis? In biochemistry we talk about de novo cholesterol synthesis, but a lot of the time it is glanced over because it would be so energetically unfavorable to synthesize it when you can get it from your diet.
I'm curious to know... if we could somehow inhibit all cholesterol absorption and forced the body to make all its own cholesterol, then how much excess energy could we burn? Could we use that as a weight loss therapy?