I am studying processes 1. stroke, 2. heart disease, and 3. cancer, and their mechanisms associated with low cholesterol which is a result of lowering cholesterol especially in elderly, Low cholesterol is associated with mortality from stroke, heart disease, and cancer: the Jichi Medical School Cohort Study. Stroke's manifestation is primary intracerebral hemorrhage ICH confirmed by many exclusion articles of other factors such as liver disease). In the heart disease, there CAD and ischemia. In the cancer, metastasis.
I started to think what could be enough general for all of these. In the energy sense, one possibility could be glycogen, since it is used as an acute energy storage in all those organs. Mechanisms could be the macro/microstructures of storage which are mostly unknown, presenting roughly 80/20 proportions. So I propose that the lack of energy causes those conditions.
I noticed that many authors use the word remnant cholesterol when speaking about the subject. I did not understand its biophysical meaning. Remnant cholesterol is an independent factor of cardiovascular manifestations apparently through the larger triglyceride-rich lipoproteins' (TRL) remnant kinetics. Remnant cholesterol does not seem to cover all aspects of low cholesterol.
How can you low cholesterol cause stroke, heart disease and cancer?