I am interested in pulse frequencies of GnRH (gonadotropin-releasing hormone) in the menstrual cycle (MC) i.e. 28 +/- 7 days. I would like to study its pulsatile nature i.e. within one MC, not same as cyclic nature within many MCs; but possible cyclic dynamics could be found in one MC too but not focus there.
GnRH releases human chorionic gonadotropin (hCG) which can be monitored by beta hCG but also by (source DynaMed Plus on Chorionic gonadotropin)
- serum progesterone, Luteinizing hormone (LH)
- estradiol levels
- ovarian US 7-14 MCD i.e. in late follicular phase
- onset of ovulation at 14 MCD
- pelvic exam
- cryptorchidism: signs of precocious puberty
Two articles on GnRH monitoring:
- Monitoring gonadotropin-releasing hormone administration by measurement of urinary steroid conjugates in the morning urine samples.
- some gene studies: Episodic gonadotropin-releasing hormone gene expression revealed by dynamic monitoring of luciferase reporter activity in single, living neurons
Possible cases to study
- Amenorrhea: Kallmann syndrome where congenitally deficiency of GnRH but how low?
However, I did not find any publication describing direct/indirect continuous measurement of GnRH.
How can GnRH be measured continuously during the menstrual cycle?