One of the symptoms of these blood cancers is sleep hyperhidrosis (aka night sweats). Also referred to as one of the B-symptoms, it may be used for prognosis.

What is the the mechanism behind the symptom?

Possibilities I came up with:

  1. Body is more likely to be infected due to immune compromise and thus a bacterial or viral etiology
  2. White cell counts may be very high causing release of cytokines which affect thermal regulation
  3. Something else

Why is there more sweating at night and not so much in the daytime?

  • $\begingroup$ When the tumor cells infiltrate other tissues and then die, there's a good chance they release some pyrogenic molecules that cause sweating. But, I don't know why at night. Hence, though, it'd be considered a paraneoplastic effect. $\endgroup$ – CKM Dec 29 '15 at 19:40

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