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As it is really beneficial for all organisms, why are animals, especially mammals (I don't know about other vertebrates) unable to synthesize cellulase enzyme in their body? Is it linked to some DNA defects or have we not evolved from cellulase producing bacteria?

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closed as primarily opinion-based by AMR, anongoodnurse, Remi.b, AliceD, MattDMo Jan 2 '16 at 0:43

Many good questions generate some degree of opinion based on expert experience, but answers to this question will tend to be almost entirely based on opinions, rather than facts, references, or specific expertise. If this question can be reworded to fit the rules in the help center, please edit the question.

  • $\begingroup$ Doesn't the bacteria flora in some higher vertebrates (ie: cows) allow for the celluase, and therefore the digestion of cellulose? We lack the bacteria and therefore the enzyme. I am not sure I understand the last part of your question, " or have we not evolved from celluase producing bacteria". $\endgroup$ – Ro Siv Jan 1 '16 at 13:14
  • $\begingroup$ i actually meant 'why cant mammals synthesize their own cellulase?' or 'why are cows dependent on bacteria for cellulose digestion?' and, by the last part i just meant that if we lack cellulase producing gene, then we must not have received it from our ancestors, which could thus not be cellulase producing bacteria ;-) $\endgroup$ – another 'Homo sapien' Jan 1 '16 at 13:41
  • $\begingroup$ I think its a symbiotic relationship, so the bacteria bet something benifital, as do we(the calories). Bacteria flora are often passed down from mother to child anyway, so why would we even need to have it in our genome? Couldn't we extend your logic to why we don't have any gene "x" that provides benifit "y"; for evolution tinkers and not engineers right? $\endgroup$ – Ro Siv Jan 1 '16 at 14:21
  • $\begingroup$ thanks, and maybe its because of those bacteria only that mammals never needed to develop that gene (if i got you right) $\endgroup$ – another 'Homo sapien' Jan 1 '16 at 14:33
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    $\begingroup$ Duplication of If a trait would be advantageous to an organism why hasn't it evolved. $\endgroup$ – AMR Jan 1 '16 at 15:53
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The answer to questions like this is just a guess (Primarily Opinion Based), and I've voted to close. But some food for thought too long for a comment:

As it is really beneficial for all organisms...

Why do you think that cellulase is so very beneficial to mammals? Animals did have cellulase (some ancient invertebrates still do, like sea squirts, abalone; crayfish have it); we may well have faulty copies of the gene (as @AMR suggested in comments.) But you presume to know we'd be better off with it. That's a belief without any objective evidence.

What might happen if we could convert cellulose into sugar? This is also important to think about. If some of that surfeit glucose in out guts were fermented into alcohol (this condition does rarely occur in humans, and the living people afflicted with this are truly afflicted), because we have a gut microbiome, we would walk around drunk much of the time (ok, maybe even only some of the time), which would make escaping predators less drunk than we were difficult. Maybe the body would be incapable of handling that level of glucose ingestion, and we'd all be T2 diabetics by the time we were just out of toddlerhood.

Humans need fiber in our GI tracts. I don't know all the reasons why we developed that way, but we do. Cellulase would do away with that. Do you know for sure that this would be good for us?

The thing is, you've made an assumption (we'd all be better off with cellulase) that has no evidence to support it at all (or, at least you have not provided any.)

It's always tricky to assume that you know what's more beneficial for a mammal in the presence of billions of mammals that seem to be doing OK. There are millions of reasons that they are doing OK. We don't know all of them, but the absence of the very thing you presume would be a benefit may be what allowed vertebrates to develop at all.

Ancient Origin of Glycosyl Hydrolase Family 9 Cellulase Genes
Structure and function of a cellulase gene in redclaw crayfish, Cherax quadricarinatus

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  • $\begingroup$ "I don't know all the reasons why we developed that way, but we do" lack of cellulase might be the reason for it. As you've said, answers to such questions are, and will be, opinion based and also, as you said "It's always tricky to assume that you know what's more beneficial for a mammal in the presence of billions of mammals that seem to be doing OK" one can never estimate how would something have affected our evolution. My point was that maybe having cellulase would have enabled us to live more easily in food scarcity. But, again I cannot assume this to be perfect solution. $\endgroup$ – another 'Homo sapien' Jan 2 '16 at 4:28
  • $\begingroup$ @aayushsrivastav - gosh, you missed my entire point, entirely. $\endgroup$ – anongoodnurse Jan 2 '16 at 4:33
  • $\begingroup$ I know, I was just justifying my point. $\endgroup$ – another 'Homo sapien' Jan 2 '16 at 4:41

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