Why do nucleic acids and mononucleotides have a negative charge physiological ph?
closed as off-topic by AMR, kmm, MattDMo, AliceD♦, anongoodnurse Jan 10 '16 at 7:43
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The phosphate group/s present in the mononucleotide or nucleic acid result in the structure having an overall slightly negative charge.
Positively charged proteins that are also present in the cell such as histones help to keep the negatively charged nucleic acid stable 'in vivo'.