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Why do nucleic acids and mononucleotides have a negative charge physiological ph?

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    $\begingroup$ Are you asking about nucleic acids or nucleotides? $\endgroup$ – Chris Jan 9 '16 at 10:25
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    $\begingroup$ This sounds like a homework question. Have you tried looking at the structure of a nucleotide? $\endgroup$ – Roland Jan 9 '16 at 14:11
  • $\begingroup$ tud.ttu.ee/im/Tonu.Reintamm/shabarova/4.1.html $\endgroup$ – CKM Jan 9 '16 at 16:48
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The phosphate group/s present in the mononucleotide or nucleic acid result in the structure having an overall slightly negative charge.

Positively charged proteins that are also present in the cell such as histones help to keep the negatively charged nucleic acid stable 'in vivo'.

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