1
$\begingroup$

There is evidence for the uptake of toxic substances like prions from the cell bodies of neurons via endocytosis. There is also evidence for prion deposition in white matter. But I haven't been able to find a discussion of whether or not endocytosis is possible from axons. Does anybody know if this is possible?

$\endgroup$
1
  • $\begingroup$ Are you asking specifically about the myelin sheathed region or are you also including the axon termini? $\endgroup$
    – AMR
    Jan 22, 2016 at 21:43

1 Answer 1

1
$\begingroup$

Short answer
In hippocampal neurons, endocytosis does occur in the axon, but only at the synapse and at varicosities.

Background
In cultured rat hippocampal neurons, Parton et al. (1992) showed that the cell body and dendritic regions are indeed capable of endyctosis. They used horse-radish peroxidase dissolved in an internalization medium. In the axon, endocytosis was only found to occur in the pre-synaptic region and in varicosities. Varicosities are points of synaptic release from the axon, outside the synapse proper.

Hence, axonal endocytosis is limited to regions where neurotransmitters are released. Presynaptic terminals often engage actively in neurotransmitter reuptake mechanisms to recycle released neurotransmitters.

Reference
- Parton et al., J Cell Biol (1992); 119(1): 123–37

$\endgroup$

You must log in to answer this question.

Not the answer you're looking for? Browse other questions tagged .