Under what conditions do tumors migrate? Is it due to hostile microenvironment conditions, drug application, mutations, or other causes? Are there any migration probability values (I am doing an in silico research) or equations to determine this?

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    $\begingroup$ There are a lot of mathematical approaches to understanding metastasis. Review articles might be a good place to start. The long and short of the biology of metastasis is it depends. Tumors are highly variable, some metastasize easily and in particular ways, others do not. It is a heavily studied area of medicine. I will add that it is probably not a "hostile microenvironment" that encourages metastasis; it is probably better to think of the proximate causes rather than such ultimate causes. $\endgroup$
    – Hans
    Jan 23, 2016 at 13:04
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    $\begingroup$ You might also want to read about the epithelial-mesenchymal transition as an initiator of metastasis. $\endgroup$
    – MattDMo
    Jan 23, 2016 at 15:47
  • $\begingroup$ So here's a sort of review article that may help you people.maths.ox.ac.uk/maini/PKM%20publications/367.pdf .. and perhaps this one as well ncbi.nlm.nih.gov/pmc/articles/PMC4626809 $\endgroup$
    – CKM
    Jan 23, 2016 at 21:12


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