This is a diagram a friend showed me about the drug aspirin, where we were arguing which enzyme it prevents. enter image description here

Aspirin is known to inhibit the production of prostaglandins. However, it also serves fit as a purpose to inhibit production of thromboxane.

My question is, does the drug inhibit enzyme a to prevent the production of both thromboxane and prostaglandins, or only enzyme B?


Aspirin and some other NSAIDs inhibit cyclooxygenase which is the first enzyme in the prostaglandin/thromboxane biosynthesis pathway if you consider first substance is arachidonic acid (a fatty acid). Generally, arachidonic acid is present in the form of a phospholipid, and if you consider that in the pathway, substance-Y is arachidonic acid and enzyme-A is cyclooxygenase.

 enter image description here From: Heckmann, Lars-Henrik, et al. "Outlining eicosanoid biosynthesis in the crustacean Daphnia." Front. Zool 5.11 (2008).


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