Tumors are known to burn glucose and secrete lactate (this is known as the Warburg effect). Where does this lactate go?
Does it steadily accumulate in the neighborhood of the tumor? This doesn't seem likely. I mean, eventually an equilibrium concentration of lactate in the neighborhood of the tumor must be reached that is balanced by some process taking lactate away from the tumor. The nature of this lactate drain is what I am asking about.
Does it enter the circulation system and is degraded somewhere else in the body (as a part of the Cori cycle)?
Is it consumed by neighboring non-malignant cells?
A combination of all of the above?