What is the cold-block temperature of ion channels? (not of nerves or axons)


1 Answer 1


The lower temperature limit of ion channels likely is dependent on various factors, including the type of channel and the recording conditions (tissue type, medium etc.). Reports on the suppression of voltage spikes (i.e., the inhibition of action potential firing) range from 1 to -20oC in squid axons, dependent on the species (Leuchtag, 2008). I couldn't find information on specific channels.

- Leuchtag, Voltage-Sensitive Ion Channels: Biophysics of Molecular Excitability (2008)

  • $\begingroup$ thanks, "suppression of voltage spikes " you mean stopping of action potentials right? The fact that an action potential cannot propagate doesn't mean that the channels are blocked but that the threshold cannot be reached right? $\endgroup$
    – george
    Commented Feb 18, 2016 at 19:21
  • $\begingroup$ @george. Yes, correct on the AP firing, I edited the answer to make that more clear. Isn't threshold increase a consequence of inhibition? I.e., I don't follow your dichotomy posed. As a rule, if you find the answer useful, we upvote the question to let others know it's a useful answer. If you think it is the answer you can accept it too. You can also downvote it when it's a poor answer. $\endgroup$
    – AliceD
    Commented Feb 18, 2016 at 20:08

You must log in to answer this question.

Not the answer you're looking for? Browse other questions tagged .