In this publication (PDF) I encountered the following word:
Binding of rupatadine to histamine H1 receptors isolated from the guinea-pig cerebellum and lung was demonstrated by inhibition of 3H-mepyramine binding; equilibrium inhibition constant (affinity) [Ki] values were 26–256 nM in the various experiments. Binding was time-dependent and pseudo-irreversible. Rupatadine was ~7.5 and 10-times more potent than the structurally-related anti-histamines loratadine and fexofenadine. H1 receptor occupation by rupatadine in guinea-pig cerebellum and lung after oral (PO) dosing was relatively rapid (with maximum binding evident at 2–4 hours post-dose) and dose-dependent; low or no binding was seen at 48 hours post-dose.
In this context, what does pseudo-irreversible mean? Since it goes on to say the binding had dissipated within 48 hours, it seems to mean persistent or long-lived. Is that correct or does it have a more specific meaning in biology?