Recently, I have been researching about big data analytics in biochemistry, and started wondering about how genome sequence compression could affect analysis.
Of all the method listed on the Wikipedia page, the reference template method is my favourite as, it not only seems effective, but also was the idea that popped into my head before I did any study regarding this topic.
But, before I implement it in a project I am working on, I wanted to know if there are any common and obvious drawbacks/limitations that the bioinformatics industry faces quite often when using this scheme.