In our body we carry a lot of bacteria. Some of them are bad for our health, but others are beneficial. For example bacteria may protect us against other pathogenic bacteria.

But is our immune system reacting to all bacteria, i.e. the good and the bad, or does it selectively target the bad? If yes, how does it differentiate between beneficial and pathogenic bacteria?

  • 1
    $\begingroup$ I believe we have commensal bacteria on and inside our body that are considered part of the innate immune system. And those flora can try to predate on the foreign flora that try and attack us. $\endgroup$
    – Ro Siv
    Mar 21, 2016 at 15:14
  • $\begingroup$ @RoSiv I think the question is why our immune system doesn't attack those bacteria which help us i.e. although they're considered part of innate immune system, what differentiates them, from pathogens, for our immune cells? $\endgroup$ Mar 21, 2016 at 15:22
  • $\begingroup$ Just because there's no answer here after 9 hours, yes the immune system would typically lash out at everything. Commensals have ways of redirecting all that anger, however, and I'll provide two reference here and here that outline some ways they accomplish this. In short: they resist some mechanisms and exert influence on others. $\endgroup$
    – CKM
    Mar 22, 2016 at 0:28
  • $\begingroup$ I don't have time to answer right now, but do some reading on immune tolerance and the microbiome. There is a lot of work going on right now to try and understand the exact details of this very process, and it's not yet clear how exactly it happens across the board. Basically, though, we and our microbiome have evolved together over millions of years, and can signal back and forth to each other. It also involves some specialized immune cells, and very complex reactions between many different species of microbiota. You could also look up "biofilms" if you're interested in that aspect. $\endgroup$
    – MattDMo
    Mar 22, 2016 at 1:53
  • $\begingroup$ Perhaps you should have a look at this review. It is quite extensive and relatively recent as well (2014). I am myself reading it; if you end up reading it before me then you may ask specific questions about the article. $\endgroup$
    Mar 22, 2016 at 8:39

1 Answer 1


The immune system is capable of recognizing pathogenic ("bad") bacteria, either by components of the innate (non-specific) or adaptive (specific) immune system. Pathogenic bacteria will have antigen on their surface that mark them as 'foreign', leading to an immune response targeted to the bacteria. In contrast, the immune system tolerates the normal flora of the body. The precise role that the human immune system takes in tolerating and regulating the populations of the normal flora is not known, it is currently a hot area of research.

Current research suggests that microbiota induces host immune tolerance to commensal bacteria directly via a microbe-associated molecular pattern (MAMP) and polysaccharide (PSA) signalling. The immune system continuously monitors the resident microbiota, and certain antimicrobial mechanisms are constitutively engaged to prevent overgrowth of the colonizing microbes: this maintains what is loosely called immune homeostasis. The mechanisms that control (intestinal) tolerance include those that:

1) minimize exposure to and 2) immune recognition of intestinal microbiota, and 3) those that down-regulate immune responses through intra-cellular and inter-cellular mechanisms.

Research has shown that he tolerance of the normal microbiota of the gut seems to require an extensive network of regulatory immune cells including Tregs and (tolerogenic) dendritic cells. Thymus-derived Tregs were discovered by Dr. Leszek Ignatowicz to be a crucial player involved in "educating" the immune system about the diverse bacterial colonies in the intestinal flora of mice. In response to the diversity of gut bacteria found in the gut, the Tregs express a 'repertoire T cell receptors' (TCR) that recognize the antigens characteristic of individual bacterial colonies in the gut. Upon engagement of these receptors, Tregs suppresses the adaptive immune response, specifically through the release of immune-modulatory cytokines such as interleukin-2. Moreover, it was found that gut bacteria can also be recognized and protected by a distinct innate lymphoid cell population (ILC) in the intestinal lining of mice. These cells behave like antigen presenting cells, and can recognize and present antigens from gut bacteria through the major histocompatibility complex class II (MHCII). But rather than activating CD4+ T lymphocytes through MHCII engagement, these ILC works by suppressing CD4+ T lymphocytes through MHCII engagement. CD4+ T lymphocytes are involved in clearing pathogen/bacteria, and thus the suppression of CD4+ T lymphocytes is involved in the immune-tolerance of normal flora.




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