What are the mechanisms that ensure consistent left-right asymmetric placement of various internal organs (heart, liver, etc) or consistent left-right asymmetric development of paired organs (brain, etc.)? At what level, and how comprehensive is our current understanding about the underlying mechanisms?

(It seems to me a mirror image is just as good as the original one in terms of fitness and functionality. But why only one specific LR asymmetry prevails? Maybe this is a misguided way to think about the problem but that motivated to ask anyway.)

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    $\begingroup$ There are two morphogens called lefty and its antagonist nodal. Their signalling and interaction gives rise to the right-left asymmetry. However, to answer your question fully, one would have to look up on how exactly are lefty and nodal regulated. $\endgroup$ – WYSIWYG Apr 26 '16 at 9:30

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