Will a de-novo synthesize infectious virus be as effective as the natural one? How important are epigenetic marks for the virus and is there a mechanism to restore them?

  • $\begingroup$ How would you "put it in a capsid"? In any case, synthetic viral genomes are well known, since the 2002 construction of synthetic poliovirus. Epigenetics are rarely important to viruses, with the possible exception of some herpesviruses and retroviruses. (More generally, the importance of epigenetics period is vastly overstated by most popularizers.) $\endgroup$ – iayork May 18 '16 at 18:34
  • $\begingroup$ @iayork I agree - "put it in a capsid" is poorly formulated and actually not important for the question. $\endgroup$ – Maxim Kuleshov May 18 '16 at 18:47

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