I am in the process of a OCR GCSE Case Study, and my question is "Do the benefits of anabolic steroids outweigh the risks, which has an obvious conclusion. I need to know the scientific name, or a scientific analysis of why it causes an increase in protein synthesis, for the binding of cortisol to understand this quote:"Anabolic steroids may block the binding of cortisol to its receptor sites, which would prevent muscle breakdown and enhances recovery.". For without enough understanding i can't explain it.

  • $\begingroup$ might be nice to know what OCR GCSE - would be a good change/update to question $\endgroup$ – Vance L Albaugh May 19 '16 at 18:56
  • $\begingroup$ Homework questions are off-topic on Biology unless you have shown your attempt at an answer. For more information see our homework policy. What research have you done so far to answer this on your own? What have you found out, and where exactly are you stuck? This is not a forum or tutorial site, we expect you to have done previous research on your own. Google searches and Wikipedia are excellent places to start, as is PubMed. $\endgroup$ – MattDMo May 20 '16 at 1:10

The intracellular receptor for cortisol is called NR3C1. http://www.uniprot.org/uniprot/P04150

To my knowledge, a direct (competitive) effect of anabolic steroids on the binding of cortisol to NR3C1 has never been proven. The anabolic effects can easily be explained by other targets. A good starting point for further reading might be this review: https://www.ncbi.nlm.nih.gov/pubmed/22101547


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