Is oxytocin (or other peptide hormones) produced from a gene through translation, or is it made some other way?

  • 1
    $\begingroup$ seems like a straightforward question...all proteins are translated from mRNA that is transcribed from DNA - that's the central dogma of molecular biology - is there a reason you think that it could be made another way? $\endgroup$ – Vance L Albaugh Jun 6 '16 at 0:56
  • $\begingroup$ Peptides like oxytocin (I think it is only 9 AAs long) seem small enough that maybe a cell would synthesize them using proteins rather than by a ribosome translating a gene for them. $\endgroup$ – user24324 Jun 6 '16 at 4:22
  • $\begingroup$ Some peptides are synthesized via nonribosomal peptide synthetases, so the question seems legit. $\endgroup$ – Ashafix Jun 6 '16 at 21:51

Oxytocin is produced by cleavage of the protein of the oxytocin/neurophysin I prepropeptide gene. The precursor peptide is cleaved by Proprotein-Convertase 1 . Mice lacking the gene which encodes for this enzyme have reduced levels of oxytocin. The final step in the biosynthesis of oxytocin is carried out by Peptidyl glycine alpha-amidating mono-oxygenase.


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