I notice that after long tests, or long periods of critical thinking, my body and mind feel noticeably tired. Why does this happen? Are the neurons in my head not firing as quickly, or is there just a perceived lack of mental concentration?

What exactly is the mechanism that makes my brain feel worn out, or at least gives me the perception of my brain being worn out?


There is ongoing research on this topic, but there is a theory known as inhibition theory. It has been defined as:

Inhibition theory is based on the basic assumption that during the performance of any mental task requiring a minimum of mental effort, the subject actually goes through a series of alternating latent states of distraction (non-work 0) and attention (work 1) which cannot be observed and are completely imperceptible to the subject.

For a more in-depth explanation, see this paragraph from Wikipedia:

Directed attention fatigue occurs when a particular part of the brain’s global inhibitory system is overworked due to the suppression of increasing numbers of stimuli. This temporary condition is not a clinical illness or a personality disorder. It is rather a temporary fatigue of the inhibitory mechanisms in the brain. According to inhibition theory, it is natural for one to alternate between periods of attention and distraction. Although one’s efforts may involve very different tasks, each incoming stimulus calls upon the same directed attention mechanism.

or this paragraph from NCBI:

Recently, it has been shown that the neural mechanisms of mental fatigue related to cognitive task performance are more complex than previously thought and that mental fatigue is not caused only by impaired activity in task-related brain regions. There is accumulating evidence supporting the existence of mental facilitation and inhibition systems. These systems are involved in the neural mechanisms of mental fatigue, modulating the activity of task-related brain regions to regulate cognitive task performance.

In short, it is now believed that the brain contains mental facilitation and inhibition systems, which control mental freshness and fatigue. Basically, when you concentrate, you actually stop all distractions from taking over (and not give more focus to the main point). This mechanism is governed by the inhibitory system of the brain. After some time, this system stops working ('it gets tired') and you become unable to pay attention towards anything. That's why it is advised that after some time of concentration, you need to distract yourself (to refresh your inhibitory system); like, say, while preparing for exams, you should have a break of 5-10 minutes after studying for about 45 minutes.

Now, why mental tiredness causes physical fatigue can be (I think) summarized by the diagram below from here:

Mechanism of physical fatigue from mental fatigue

The exact process at this part is rather very interesting. Here, the neurons are not firing as quickly as they do normally. See this Wikipedia page:

Physical fatigue can be caused by a lack of energy in the muscle, by a decrease of the efficiency of the neuro-muscular junction or by a reduction of the drive originating from the central nervous system. The central component of fatigue is triggered by an increase of the level of serotonin in the central nervous system. During motor activity, serotonin released in synapses that contact motor neurons promotes muscle contraction. During high level of motor activity, the amount of serotonin released increases and a spillover occurs. Serotonin binds to extrasynaptic receptors located on the axon initial segment of motor neurons with the result that nerve impulse initiation and thereby muscle contraction are inhibited.

The same might happen in the case of mental fatigue i.e. the excess serotonin released from frontal or parietal lobes, or even the inhibition system itself, can cause the same effect i.e. inhibition of muscle contraction.


  1. Inhibition theory
  2. Directed Attention Fatigue
  3. Neural mechanisms of mental tiredness
  4. Mechanism of physical fatigue from mental tiredness
  5. Fatigue
  • $\begingroup$ this is awesome. Can you please add some references for us who would like to read more? Thanks! $\endgroup$ – nbafrank Jul 13 '16 at 3:30
  • $\begingroup$ I've already done, I'll add 'em separately too. Sorry BTW :) $\endgroup$ – another 'Homo sapien' Jul 13 '16 at 3:54

Well, there's a proximal answer and a distal answer. The distal one:

When we study zoology (and one must study zoology in order to understand the human being), we see the evolution of cells taking us back to the first animals, like Porifera, where important functions such as communication, movement and digestion - were all performed by the same type of cells.

Even in the more complex triploblastics, like Gymnotiformes and others, we still see muscle cells emiting electric discharges, like neurons do.

So, the brain is not totally dissimilar to the muscle, and just like fermentation in the muscle produces Lactic Acid, some similar system might cause us the need for rest and sleep (a need universal in the animal kingdom, by the way - the "laborious" individual ant spend more time sleeping than working, it seems).

When we do the same sort of tiresome mental work (processed in the same nerves and brain areas), the fuel - oxygen - must get scarce in that region, just like in the muscles, where the lack of oxygen activates the alternative fermentation, leading to painful skeletal muscle cramps.

So I take a guess: can it be the Lactic Acid that causes us to be "mentally tired", in a process similar to a cramp? (Though certainly different - the pain looks different - and probably more complex, enriched by layers of signals and alternative resources, increasing the versatility and effectiveness of the brain in a species where mental skills are the only weapon left.)

  • $\begingroup$ I could have have given an upvote if you had references. "a need universal in the animal kingdom" you know that some (though less) animals don't need sleep at all? $\endgroup$ – another 'Homo sapien' Nov 25 '16 at 17:47
  • $\begingroup$ It was a lecture I attended many years ago, about sleep and dreams in the animal kingdom. The need for sleep is widespread in the animal kingdom. If I'm not wrong, Edward Wilson wrote about how ants spend more time sleeping than working (in Sociobiology or The Insect Societies? Not sure.) Some migratory animals "don't sleep", but actually each half of their brains sleep separately. $\endgroup$ – Rodrigo Nov 25 '16 at 17:56
  • $\begingroup$ I think even that much of a reference would work, if you're sure about it. I think you should have a look at this. $\endgroup$ – another 'Homo sapien' Nov 25 '16 at 18:01
  • 1
    $\begingroup$ @another'Homosapien' Nice link. That's what I meant: "Sleep is pretty much universal. Practically every animal sleeps in one way or another." $\endgroup$ – Rodrigo Nov 25 '16 at 19:40

protected by Community Jul 12 '16 at 23:32

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