GTP and ATP are similar structures with the adenosine and guanosine groups differing. Both are involved in a vast array of biological functions.

However it has been shown that in certain cases, GTP and water can mimic ATP (Niefind et al., 1999).

An image of GTP and ATP side by side. GTP has an additional NH2 group. ATP has an NH2 group where GTP has a double bonded oxygen.

Are there examples where ATP has acted as a mimetic of GTP? Or in other words, are there any proteins that can't discriminate between GTP and ATP very well?

  • 2
    $\begingroup$ There are certainly some enzymes that don't discriminate (well) between the two purines. Is that what you mean by mimic? $\endgroup$ – Roland Jul 8 '16 at 6:27

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