So I was reading this paper and found a figure as below: enter image description here I understand that [LEAM] means any of LEAM residues, pS is phosphoserine and X means any amino acid residue.

What is [+] here ? Is both R and Ar arginine itself?


Ar means aromatic and + means positively charged residues. However, this is not a standard code (as of now).

From the same paper:

Sequences closely matching these optimal binding motifs, R-X-[Ar/S]-[+]-pS-[LEAM]-P and R-[S/Ar]-[+]-pS-[LEAM]-P, denoted as mode 1 and mode 2 consensus sequences, were found to be present in many known 14-3-3 ligands ( Yaffe et al. 1997), where Ar denotes aromatic residues and + denotes basic residues.

  • $\begingroup$ Sorry I should have read the paper in detail. My mistake. $\endgroup$ – dexterdev Jul 22 '16 at 13:02

From the mention of “aromatic residues” in the figure legend (in a different context) I assume Ar stands for aromatic residues. Ar is certainly not an abbreviation for arginine.

I would guess that [H/+] means either histidine or any positively-charged residue.

I think that the authors of the paper should have pointed this out in the figure legend, and that the referees should have insisted on it.

  • $\begingroup$ Authors cannot be blamed, here. This is clarified in the introduction but a note in the figure legends would have been helpful. $\endgroup$ – WYSIWYG Jul 22 '16 at 12:17
  • $\begingroup$ Ok, I'll moderate my remark. $\endgroup$ – David Jul 22 '16 at 12:18

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