So I was reading this paper and found a figure as below: I understand that [LEAM] means any of LEAM residues, pS is phosphoserine and X means any amino acid residue.
What is [+] here ? Is both R and Ar arginine itself?
Ar means aromatic and
+ means positively charged residues. However, this is not a standard code (as of now).
From the same paper:
Sequences closely matching these optimal binding motifs, R-X-[Ar/S]-[+]-pS-[LEAM]-P and R-[S/Ar]-[+]-pS-[LEAM]-P, denoted as mode 1 and mode 2 consensus sequences, were found to be present in many known 14-3-3 ligands ( Yaffe et al. 1997), where Ar denotes aromatic residues and + denotes basic residues.
From the mention of “aromatic residues” in the figure legend (in a different context) I assume Ar stands for aromatic residues. Ar is certainly not an abbreviation for arginine.
I would guess that [H/+] means either histidine or any positively-charged residue.
I think that the authors of the paper should have pointed this out in the figure legend, and that the referees should have insisted on it.