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Could a whole set of artificial organism-cloning process only be operated on the somatic nuclear donor ,which means for example ,can we extract the somatic nuclear from animal "A" and put it into the egg cell plasma also from animal "A" then implant it into the animal"A"'s uterus to clone "A" ?

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Could a whole set of artificial organism-cloning process only be operated on a somatic nuclear donor?

No, this would not be possible. Single-cell reprogramming would enable you to reset the potency status of that cell up, yielding an embryonic stem cell (ESC). However, ESC do not have the ability to generate extra-embryonic structures (e.g. placenta), which are known to be required for providing oxygen and nutrients to the embryo, amongst other relevant functions.

Theoretically, it could be possible to replicate the embryological environment, and I think this is the second part of your statement. Nevertheless, in practice this is not possible... the amount of signals and parameters that one would need to control simultaneously is far too extensive.

I don't quite see the point of having an enucleated egg and performing somatic cell transfer, when you're not really interested in implantation in utero. Somatic cell reprogramming would be sufficient (see iPSC)

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  • $\begingroup$ thanks ! Now I gain some new knowledge now , but there is a little bit misunderstood , what I mean is that ,for example ,if we get a somatic cell from animal "A" , can we just transfer that cell to animal A's uterus to clone animal"A",instead of finding another surrogate mother or egg cell donor? $\endgroup$ – Snake Aug 7 '16 at 23:22
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    $\begingroup$ @Snake From your comment and your newly edited question I see what you mean. You are wondering whether it is possible to clone an animal by using its own somatic cells AND eggs. I do not have extensive experience with transgenic production, but I have a hypothesis on why the same female is not used as a donor and for implantation: oocyte extraction is an invasive method that may be destructive (i.e. the donor female dies). Therefore, it is not possible to use the same female and a foster mother is required. $\endgroup$ – rlluc Aug 9 '16 at 9:50
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we use egg cell because it has tendency to cleave and provide nourishment to the developing embryo while this can not be obtain by any other somatic cell. if in case of mammals the egg is also capable to adjust in the placenta and grow and obtain required objectives as nourishment and exchange of materials with the mother body.

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    $\begingroup$ Welcome to BiologySE - we always appreciate references to back up claims made by users in questions and answers. Can you add some references to this answer so that other users can follow along? $\endgroup$ – Vance L Albaugh Jun 10 '17 at 13:04

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