I'm wondering what produces the feeling of hunger in humans. Checking Wikipedia revealed that leptin and ghrelin are two hormones involved. I've also read that the digestive system produces its own melatonin.
Because melatonin is related to circadian rhythm and the biological clock,Is melatonin involved in feeling hungry?Is there a circadian pattern to the levels of leptin and ghrelin in humans?
Yes, absolutely. A major focus of understanding obesity, diabetes and other metabolic disorders are targeted to understanding the circadian (and other cyclical nature) systems in neurobiology and endocrinology. I can speak within the study of diabetes, there is an observed diabetic "dawn effect" in which there is an early morning (dawn) spike in blood glucose. The exact mechanism for this spike in blood glucose is not fully known, but the general circadian nature is intriguing and would suggest a dominant hormonal cause.
Some other review articles may be found here. An overall review of homeostatic balance as it relates to the central nervous system and apetite regulation. The second review more closely focuses on the biochemistry and endocrinology of central and peripheral regulation on food intake and physical activity.
The expression of 5-HT2C receptors in the hippocampus follows a diurnal rhythm, just as the serotonin release in the ventromedial
nucleus, which is characterised by a peak at morning when the
motivation to eat is strongest.