Is it possible that the falling of the concentration of a protein below a threshold triggers the release or production of another protein?

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    $\begingroup$ Welcome to SE Biology. Your question is very broad. You need to provide some context — is this a homework question or do you have a specific system in mind? Why are you asking this question and what attempts have you made to solve it yourself. See "How do I ask a good question". Oh, and please spell-check your titles at least. I'll correct this one. $\endgroup$
    – David
    Commented Aug 7, 2016 at 21:02
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    $\begingroup$ A: Yes. There are too many examples to list. $\endgroup$
    – James
    Commented Aug 19, 2016 at 3:53

1 Answer 1


Of course, that is possible. I'll give a simple example. If your protein (X) is an inhibitor of the other protein (Y), then when X falls, Y will rise. This would not really be "thresholded".

There are many mechanisms that can lead to thresholding which include co-operativity (in the action of X) and positive feedbacks. How these mechanisms work would be a different question altogether. (A quick read would be this wikipedia article).

  • $\begingroup$ Thank you very much. I'm a physicist and I'm interested in how axons can regulate its length. In a model I'm dealing with, the concrentration of a protein falls below a threshold when the axon reaches a distinct length. The question is if this falling below the threshold can stop the axon from growing. $\endgroup$
    – Peter123
    Commented Aug 8, 2016 at 20:53
  • $\begingroup$ @Peter123 As I mentioned above, it is possible. If you are asking an example of what those proteins X and Y may be in case of axon growth then I think you should do that literature mining yourself. There may be several examples. Check out a review on this topic. $\endgroup$
    Commented Aug 9, 2016 at 5:42

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