I am having a bit of trouble interpreting flow charts given in my biology question sets.
The Question is :
In which of the following options does each substance play two different roles in the series of events from plaque ruprture to MI?
- ADP and collagen
- Collagen and Fibrinogen
- Antithrombin III and collagen
- Fibrinogen and antithrombin III
The answer is:
"Fibrinogen binds to the glycoprotein (GO) IIb/IIIa leading to the cross-linking of platelets. It is also converted into fibrin which stabilises these cross-links and leads to aggregation. Antithrombin III inhibits the activation of the coagulation cascade and also inhibits the production of thrombin. The answer is D.
My issue is:
This answer doesn't make sense to me.
The fibrinogen square connects to the "Cross links-platelets via GPIIb/III receptor" square, which THEN connects to the "Platelet cross-links stablised" square (i.e. "Fibrinogen" doesn't directly connected to "Platelet cross-links stablised").
Why does this count as "two different roles" yet e.g. "Exposure of collagen" connecting to "platelets adhere to collagen" which connects to "Platelet activation release of TXA2 and ADP" not count as "two different roles".