I have a question about this image below. Do you think that the pink arrow is actually going in the right direction?
I would suggest a LTO sequence and not LOT, since it is in the T state that ADP + Pi is converted in ATP.
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Sign up to join this communityI have a question about this image below. Do you think that the pink arrow is actually going in the right direction?
I would suggest a LTO sequence and not LOT, since it is in the T state that ADP + Pi is converted in ATP.
Yes, the arrows are correct. However, it's not immediately clear what they're trying to show.
ATP synthase can act as a generator or a motor. Interactions cause rotation of the F0 subunit and the 𝜸 subunit's axle has a kink in it which deforms the stationary F1 subunits (the axle can turn either way to act as a generator or a motor). Read more at PDB's ATP synthase 101.
The black arrows in the asker's diagram are implying the movement of ADP or ATP (generation) in and out of the catalytic site. The pink line implies the movement of the axle kink and not the transition of ADP+pi->ATP.
Let's focus on the left-hand subunit across the subfigures and it makes more sense (ADP and Pi go in, protein "closes" and ATP is formed, ATP is released). Meanwhile, the "kink" completes a full rotation.